22nd June 2018 (University of Reading, UK)
EIT Food Quisper consortium, hosted by the University of Reading, met to review progress in June. Attendees included representatives from each of the seven beneficiaries.
Presentations from each of the beneficiaries provided updates on the work and started with the new Developer Platform, created by the hyve (NL). Technische Universität München described how the Quisper Scientific Advisory Board (QuiSAB) might be organised and managed including the tenure of the QuiSAB members. Business and governance models, including the progress on establishing Quisper ASBL, were proposed by shiftN whilst the University of Reading presented results from their Diet Quality Score and eNutri App research, and the development of a food preferences database. EuroFIR presented an update on the dissemination and stakeholder engagement plan and the Quadram Bioscience Institute outlined overall progress of the project.
In addition to the presentations, beneficiaries enjoyed a rare opportunity to network with their colleagues and discuss future activities. The next meeting will be in Munich (DE) during December 2018.
14th June 2018 (Rotterdam, NL)
Koppert Biological Systems hosted the first cross-KIC event amongst partners from the European Institute of Innovation and Technology (EIT) Food and Health Communities. The event showcased examples where the two communities have been successful independently but also ways in which they might work together in other EIT-funded projects. Speakers included Menno Kok (Director of EIT Health Belgium-Netherlands), Angelo Vermeulen (NASA), Imran Afzal (PepsiCo).
This event illustrated interconnections between these sectors and the willingness to engage more amongst projects with common interests. Menno Kok described how EIT Health could fund more prevention-related projects in coming years, and revealed there will be joint EIT Health and EIT Food funding calls in the future, related to education, business creation and sustainability. There will also be a joint innovation strategy for cross-KIC projects linking food and health. Importantly, for Quisper, Menno highlighted research in disease prevention, specifically the impact on individuals who are aware of a genetic predisposition and what it means in terms of health and dietary behaviours.
Angelo Vermeulen (NASA) talked about the many food innovations happening in the space sector (e.g. 3D-printed food to space farming) and discussed how NASA researchers monitor the composition of foods consumed. Understanding links between different types of food data (e.g. production methods and composition) is important for Quisper.
Slides are available here < https://www.slideshare.net/EITFood/the-benefits-of-biologicals-for-food-health-industries>
Photos are available here < https://www.facebook.com/pg/EITFood.eu/photos/?tab=album&album_id=2134182613492909>
According to Grimaldi et al. (2017) (Eurogenetica Ltd, UK), there is a lack of regulations and guidelines that enable researchers to assess the validity of diet-gene interactions and, thus, companies to commercialise reputable products for consumers. To fill this gap, the authors have created a draft framework that allows scientists, healthcare professionals, and public policy makers to assess the quality of scientific evidence used to support personalised nutrition advice.
Elaborating this framework included review of a variety of documents such as guidelines for medical genetic testing and public health nutritional recommendations. However, the information obtained was not sufficient to assess accurately the evidence for genetics-based personalised nutrition advice. Most did not include the effects of diet-gene interactions on health outcomes, which is essential for evidence-based nutrigenetic advice. Thus, the framework proposes criteria to validate genetic-based dietary advice, including study design and quality, and biological plausibility (diet-gene interaction[s]).
Until now, research has described show some well-defined diet-gene interactions that support the idea that personalised nutrition advice might have a long-term benefit on health. It is important, however, to elaborate individualised advice based on sound evidence to gain trust and acceptance.
Personalised nutrition is impacting public perceptions of healthcare and has the potential to change for the better public health, reducing the incidence of non-communicable diseases (e.g. obesity, diabetes, cardiovascular disease, etc.) and the costs associated with treatment and care.
Read more here: https://genesandnutrition.biomedcentral.com/articles/10.1186/s12263-017-0584-0
Ordovas et al. (2018) (Tufts University, Boston, MA, USA) have suggested that more research on personalised nutrition is needed to deliver advice based on robust scientific evidence. They advised that studies should be designed in line with clinical research (i.e. randomised controlled trials, RCT) and include a range of “omics” techniques (e.g. metabolomics, microbiomics, etc.), and more guidelines on the use of genotype-based nutritional advice should be developed.
Currently, very little evidence has been published on gene-diet interactions from RCTs; most of the current personalised nutrition advice comes from observational studies using existing risk factors (e.g. cholesterol and cardiovascular disease risk). One exception is the Food4me study, which investigated the impact of personalised dietary advice amongst 1600 individuals and showed personalised information was more effective than generic advice at changing dietary and lifestyle behaviours for the better.
The term “personalised nutrition” can be defined as “an approach that uses information about individual characteristics to develop targeted nutritional advice, products or services”. The goal of personalised nutrition is to generate healthy eating advice using genetic, phenotypic, nutritional and clinical data, in combination with individuals’ goals, to promote healthy eating. The idea behind this concept is that a more personalised nutrition advice has a stronger effect on an individual’s health than more generic public health approaches. This new paradigm for dietary advice has arisen from:
Read more here (https://doi.org/10.1136/bmj.k2173)
- A better understanding of how nutrition affects the health of populations and individuals
- Increased availability and uptake of fitness trackers, mobile apps and other devices that allow tracking and or continuous measurement of some biomarkers (e.g. activity).
- New analytic tools that translate data into easy-to-understand recommendations.
Providing personalised nutrition advice through apps on mobile devices could be an effective tool to address serious and persistent public health problems (e.g. obesity, cardiovascular disease, diabetes mellitus). This approach has been tested using an app developed by the University of Reading (UoR).
Results from an online study (EatWellUK) involving 324 UK participants evaluated the eNutri app using three well-established questionnaires:
Volunteers were assigned to one of two groups, based on age (18 – 59 and 60+ years) and screen size (mobile, tablet, laptop/desktop). Suitability for online studies was determined by completion of all questionnaires without assistance across all age groups and a SUS score greater than 70.
Wider use of online and electronic devices would enable healthcare professionals and providers to monitor and affect changes in intake and lifestyle easily and efficiently. However, for apps like eNutri to benefit consumers and healthcare, they must be user-friendly as well as scientifically validated.
The eNutri app is being trialled in the UK and Germany as part of the Quisper project funded by EIT Food (ID 18064).
- Baecke questionnaire for evaluating physical activity
- Food4Me (http://www.food4me.org/scientific-publications) food frequency questionnaire (FFQ)
- System usability scale (SUS) questionnaire, a tool used for evaluating evaluate a hardware, software, mobile devices, websites and applications (apps)
Read more here (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202006)
 University of Reading is one of the leading partners in the Quisper Project.